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If there is already resistance to isoniazid, it will be easier to select resistance to rifampicin as well, thus settings with a high prevalence of initial isoniazid resistance will have a higher likelihood of experiencing an increase in multidrug-resistant tuberculosis.

As will be shown further on that acquisition of drug resistance appears, at least from some rather solid evidence, to be facilitated in the presence of HIV infection.

Fixed-dose combinations of several drugs have tremendously helped to reduce errors in prescription. However, it has been erroneously argued that fixed-dose combination tablets reduce the risk of acquisition of drug resistance because patients cannot be any more selective in the number of drugs they are taking, but omitting pointing out at the danger that may arise if patients are selective in the number of tablets, leading to sub-inhibitory doses of all drugs in the combination.