Interventions for Tuberculosis Control and Elimination
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The active component of pyrazinamide, pyrazinoic acid had been synthesized in 1934, but its activity against M. tuberculosis was then not recognized. Pyrazinamide is active only against M. tuberculosis. It requires an acid milieu for its activity. It reduces the risk of relapse and has allowed shortening the duration of chemotherapy when added during the first two months of treatment.
