Slide 079 Interventions for Tuberculosis Control and Elimination
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Directly observed therapy ensures that the medications are taken as prescribed, thus preventing irregularity and sub-inhibitory concentrations. In this setting in Texas, directly observed therapy led to a significant reduction in the frequency of multidrug-resistant (isoniazid plus rifampicin resistance), relapse and acquired drug resistance.  As expected, primary resistance was affected only with some delay.

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Last update: September 29, 2010