Interventions for Tuberculosis Control and Elimination
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Robert Koch published an extensive report in 1884 of his discovery of the tubercle bacillus as the etiologic agent of tuberculosis, announced and published two years earlier. In the extensive report, he also published beautiful color drawings of his observations. During experimentation, Koch also discovered what is now known as the "Koch phenomenon": an experimental primary infection is often accompanied by very little tissue necrosis, while reinfecting the same animal later leads to extensive tissue distruction.
