Interventions for Tuberculosis Control and Elimination
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largely based on the re-analysis of the Alaska studies, the American Thoracic Society and the United States Centers for Disease Control and Prevention changed their recommendations for preventive therapy in 2003. For isoniazid, the nine-month regimen is now the recommended standard. The six-month regimen is explicitly discouraged for patints with HIV infection, with fibrotic lesions, or for children, thus the perhaps three most important indications for preventive therapy.
If rifampicin is used, a 4-month regimen of rifampicin alone is recommended.
